Herpes cycles between periods of active disease followed by periods without symptoms.
The first episode is often more severe and may be associated with fever, muscle pains, swollen lymph nodes and headaches.
Infections are categorized based on the part of the body infected. It may result in small blisters in groups often called cold sores or fever blisters or may just cause a sore throat.
Over time, episodes of active disease decrease in frequency and severity.
They are transmitted by direct contact with body fluids or lesions of an infected individual.
HSV is the most common cause of viral encephalitis.
When infecting the brain, the virus shows a preference for the temporal lobe.
HIV/AIDS, immunosuppression in solid organ transplants). Neonatal herpes simplex is a HSV infection in an infant.
It is a rare but serious condition, usually caused by vertical transmission of HSV-1 or -2) from mother to newborn.
The virus interacts with the components and receptors of lipoproteins, which may lead to its development.
Herpes transmission occurs between discordant partners; a person with a history of infection (HSV seropositive) can pass the virus to an HSV seronegative person.
As a result of primary infection, the body produces antibodies to the particular type of HSV involved, preventing a subsequent infection of that type at a different site.
In HSV-1-infected individuals, seroconversion after an oral infection prevents additional HSV-1 infections such as whitlow, genital herpes, and herpes of the eye.
During immunodeficiency, herpes simplex can cause unusual lesions in the skin.